Heroin may cause a man to feel invincible. Cocaine may make a man feel like he can run past the speed of light. Ecstasy may make a man feel like every nerve in his body is coming alive. Still, no matter how potent those substances may be, it's love that is the most potent drug of all.

This fact is especially true when Juan awakens from a two-month coma with a partial memory loss after a shootout. The only thing he remembers is a DEA agent Jessie, who blackmailed him to bring down his boss, and Angie, Juan's secret lover and the missing wife of the deceased drug kingpin Don Emilio. Although the events leading to Juan and Don Emilio's shooting are vague and Angie might have played a role in both, Juan's love for her wins any doubts. When Jessie returns to his life with another "deal," Juan decides to help her with the promise that Angie's life is spared. Juan becomes DEA's secret weapon with orders to find the "Black Widow" a mystery woman who has taken over Don Emilio's business.